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- _6 wasQuotedFrom 11158308 provenance.
- _6 value "# Ariadne: Results (Fig. 9 A) show that the presence of etaPKC triggers the activation of ERK5 to phosphorylate MEF2C in a manner that is dependent on MEK5. [Regulation] Consistent with the role of the aPKCs in the MEK5-ERK5 pathway, we show that zetaPKC and lambda/iotaPKC activate the Jun promoter through the MEF2C element, a well-established target of ERK5. From all these results, we conclude that MEK5 is a critical target of the aPKCs during mitogenic signaling." provenance.