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- _4 wasQuotedFrom 10482544 provenance.
- _4 value "Treatment of peripheral blood mononuclear cells with CD40L upregulated the HIV-receptor CD4. It was also upregulated at mRNA level. CD4 expression, while generally undetectable on freshly isolated B lymphocytes was detected in approximately 15% of the cultured population by day 8. The HIV-1 luciferase virus single round infection was specifically blocked by anti-CD4 MAb RPA-T4. Thus HIV-1 infection of CD40-activated B lymphocytes is mediated by CD4." provenance.