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- _4 wasQuotedFrom 11466388 provenance.
- _4 value "IL-18 can act in synergy with IL-12 in regulating IFN-g (18). However, IL-18 also up-regulates other cytokines, such as TNF-a, IL-1b, and IL-8 in non-CD141 PBMCs, resting T cells, and NK cells (19). IL-18 up-regulates GM-CSF in PBMCs (20) and also in synovial membrane cultures, directly affecting macrophages to stimulate cytokine production (21)." provenance.