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- _4 wasQuotedFrom 8910536 provenance.
- _4 value "Osteoclast formation was higher in ovariectomized (OVX) mice than sham operated mice, ovariectomy also increased the mononuclear cell secretion of interleukin IL-1, tumor necrosis factor and M-CSF production. The production of M-CSF protein and mRNA via IL-1 was lowered by the treatment of estrogen or IL-1 receptor antagonist (IL-1ra bound to IL-1 receptors and competed with both IL-1 alpha and IL-1 beta without detectable IL-1 agonistic effects) in ovariectomized bone marrow cells." provenance.