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- _5 wasQuotedFrom 18259193 provenance.
- _5 value "The mechanism by which HIF mediates these effects appears to be through inhibition of C-Myc activity. The mechanism by which HIF mediates these effects appears to be through inhibition of C-Myc activity. HIF-1 was found to negatively regulate C-Myc activity and mitochondrial respiration through transcriptional activation of the C-Myc repressor, MXI-1, and through regulation of C-Myc protein stability." provenance.