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- _8 wasQuotedFrom 19570984 provenance.
- _8 value "However, Rin1Δ expression did not complement Rin1 knockdown defects but instead caused further inhibition of cell proliferation (Fig. 4E). These results suggest that a functional Vps9 domain is critical for Rin1 activity in EGFR-mediated cell proliferation. To verify that the Rin1 Vps9 domain was important for A549 cell proliferation, Rin1Δ or wild type Rin1 expression constructs were transfected into A549 cells and assayed for colony formation (Fig. 5, A and B). Only Rin1Δ expression but not wild type Rin1 expression resulted in decreased cell proliferation. These results indicated that Rin1 lacking a functional Vps9 domain acted as a dominant negative, suggesting that the trafficking roles of Rin1 were mediating EGFR proliferative signaling in A549 cells." provenance.