Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAgT0Rwlgu2ktt--odpuYtpvkHhlL-bV-cn5gEu8obPK0#_5> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _5 wasQuotedFrom 18996370 provenance.
- _5 value "Microarray analysis using a tetracycline-inducible LMX1B expression system in HeLa cells revealed that a subset of NF-kappaB target genes, including IL-6 and IL-8, are upregulated in LMX1B-expressing cells. Chromatin immunoprecipitation demonstrated that LMX1B binds to the proximal promoter of IL-6 and IL-8 in vivo, in the vicinity of the characterized kappaB site, and that LMX1B recruitment correlates with increased NF-kappaB DNA association. IL-6 promoter-reporter assays showed that the kappaB site and an adjacent putative LMX1B binding motif are both involved in LMX1B-mediated transcription. " provenance.