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- _5 wasQuotedFrom 12893815 provenance.
- _5 value "MyD88 also binds to IRAK-4 and thereby facilitates IRAK-4 phosphorylation of critical residue(s) in the kinase activation loop of IRAK-1, triggering IRAK-1's own kinase activity. Once activated, IRAK-1 likely autophosphorylates residues in its N terminus. TRAF6 is also recruited to the receptor complex via interaction with IRAK-1." provenance.