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- _4 value "Here we tested how expression of COUP–TFI affected TCDD activity from the natural ERE sequences from the pS2 and c-fos promoters in transiently transfected MCF-7 cells. E2 alone stimulated a 1.6- to 2.1-fold induction in luciferase activity from the pS2 ERE (Fig. 8A). 4-OHT blocked the E2 activity, indicating the specificity of the induction by ER. TCDD alone gave a 1.4-fold induction in luciferase activity. Cotreatment with TCDD suppressed E2-stimulated luciferase activity. COUP–TFI inhibited both E2- and TCDD-stimulated luciferase activity from pS2." provenance.