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- _6 wasQuotedFrom 15345710 provenance.
- _6 value "In the experiment illustrated in Fig. 5B, PC3-LRIG1 cells were treated with and without tetracycline to induce LRIG1 expression, and a time course of EGF stimulation of the cells was carried out. Lysates were immunoblotted with anti-phosphotyrosine and anti-EGFR antibodies. In the presence of LRIG1, EGFR responded less efficiently to EGF as determined by blotting autophosphorylated receptors with anti-phosphotyrosine. Interestingly, LRIG1 expression also resulted in an accelerated loss of EGFR." provenance.