Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8#_4> ?p ?o ?g. }
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- _4 wasQuotedFrom 10837486 provenance.
- _4 value "We report here that the phosphorylation of BAD at Ser-155 within the BH3 domain is a second phosphorylation-dependant mechanism that inhibits the death promoting activity of BAD. Phosphorylation at Ser-155, similar to phosphorylation at SER-112 and Ser-136, inhibits BAD-induced death-promoting activity but does so in a different manner. Phosphorylation at Ser-155 does not induce 14-3-3 binding and ctoplasmic sequestration but instead directly blocks BH3-dependent dimerization with Bcl-XL. The binding of Bcl-XL by the BH3 domain may cause Bcl-XL to release APAF-1 or regulate other Bcl-XL activites resulting in a caspase 9-initiated cascade of proteolysis and induction of apoptosis." provenance.