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- _4 wasQuotedFrom 17511588 provenance.
- _4 value "Nox2 is a critical component of endothelial NADPH oxidase (38), and its expression and Nox2-dependent ROS production are increased by oxidized LDL, endothelin-1, angiotensin II, VEGF, and angiopoietin-2 in ECs (99). Nox1 is involved in shear stressinduced ROS production which is required for monocyte adhesion (93) and stimulates branching morphogenesis in sinusoidal ECs (55). Nox4 is most abundantly expressed in ECs, and involved in basal- (2) and Ang II-induced (109) O2- production. Moreover, p47phox is involved in cytokine, growth factor, or shear stress-stimulated ROS production in ECs (48, 67, 107)." provenance.