Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAi37dkbs6AUdclgV4eZ9avgfJGoGXOlnDf5zOa2mC6T8#_4> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _4 wasQuotedFrom 11328805 provenance.
- _4 value "HRG Stimulates Tyrosine Phosphorylation of beta -Catenin through the PI 3-Kinase Pathway and Its Association with HER2-- Because HRG has been shown to activate several signaling pathways (4, 5, 7, 10, 36), we next examined the nature of the signaling pathway responsible for HRG-induced beta -catenin tyrosine phosphorylation. Our results showed that the HRG-increased phosphorylation status of the immunoprecipitated beta -catenin was completely reduced by blocking the PI 3-kinase pathway by pharmacological inhibitor LY294002 (PI3K inhibitor) and only modestly reduced by inhibition of the MAP kinase pathway with the chemical inhibitor PD98059 (MEK1 inhibitor) (Fig. 2A). " provenance.