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- _6 wasQuotedFrom 16873684 provenance.
- _6 value "This indicates that ERK1/2, reported to be located downstream of PKA, participates in the PKA-mediated CREB phosphorylation elicited by glucose. In ERK1/2-downregulated MIN6 cells by siRNA, glucose-stimulated CREB phosphorylation was highly reduced and CREB protein content was decreased by 60%.% blockade of ERK1/2 activity with PD98059 caused a significant decrease in CREB protein level" provenance.