Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAkO7HD0wSgJ-lNC9dGlFbDUkf47Zzwh-xgZrkfZz6OeQ#_2> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _2 wasQuotedFrom 14500382 provenance.
- _2 value "We found, when introduced into an interleukin 3-dependent cell line, TPR-MET induces factor independence and constitutive tyrosine phosphorylation of several cellular proteins. One major tyrosine phosphorylated protein was identified as the TPR-MET oncoprotein itself. Inhibition of the Met kinase activity by the novel small molecule drug SU11274 [(3Z)-N-(3-chlorophenyl)-3-([3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide] led to time- and dose-dependent reduced cell growth." provenance.