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- _5 value "from full text - IFN-a initiates the activation of STAT-1 followed by the induction of IFIG [35–37]. Although it is reported that IL-27 activates not only STAT-1, but also STAT-2, STAT-3, STAT-4 and STAT-5 in T cells [2,4,14,38], and activates STAT-3 in macrophages [39], it has not been clear whether the cytokine activates STAT-1 in macrophages. To determine whether IL-27 activates STAT-1 in CD4 T cells and MDM in our culture system, Western blot analysis was performed. The assay demonstrated that both cytokines induced the phosphorylation of STAT-1 in CD4 T cells and MDM (Fig. 2d)." provenance.