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- _5 wasQuotedFrom 15916985 provenance.
- _5 value "The mechanism of adiponectin action in endothelial cells has been further investigated. TNF-A activates nuclear transcription factor NF-KB in these cells by stimulating protein kinase NIK (NF-kB inducing kinase), which phosphorylates the NF-kB inhibitor, IkB, initiating its degradation and thus leading to NF-KB activation. NF-KB stimulates the expression of cytokines and adhesion molecules involved in the inflammatory process." provenance.