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- _4 value "ranscriptional response of selected cellular genes in Jurkat T cells upon SDF-1 exposure. Among the genes which showed a continuous increase in their expression following SDF-1 exposure were those involved in detoxification, DNA repair, apoptosis, TCR signal transduction, cytokinesis, cell adhesion molecules, chemokine receptors, and IFN-related molecules. The effects of MEK and PI3K inhibitors (50 µM PD098059 (20 21 ) and 20 µM LY294002 (22 ), respectively) on the expression of these genes are also shown. Jurkat cells were exposed to SDF-1 in the presence of the inhibitors for 6 h without FCS. Reference mRNA was obtained from cells exposed to the inhibitors but not to SDF-1. The expression ratios were determined as described in the legend to Fig. 1. " provenance.