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- _7 wasQuotedFrom 11090623 provenance.
- _7 value "Our results show that VEGF can induce activation of the key integrins involved in angiogenesis, thereby establishing a mechanism by which the VEGF/VEGFR system can regulate cellular adhesive and migratory responses. Prothrombin, recently identified as an activation- dependent ligand of aVb3 (Byzova and Plow, 1998), supported limited adhesion of nonstimulated HUVECs; however, when these cells were stimulated with as little as 10 ng/ml VEGF165, adhesion to prothrombin increased by more than 10-fold. The increment in adhesion was similar to that induced by PMA" provenance.