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- _7 wasQuotedFrom 12893815 provenance.
- _7 value "Pellino 1 is required for IL-1-induced NF-κB activation and IL-8 gene expression (30). Pellino 2 has also been shown to be involved in IL-1R/TLR signaling pathways (31). Following IL-1 stimulation, IRAK-1 and Pellino 2 associate to form complexes. Ectopic expression of a Pellino 2 antisense construct was shown to inhibit IL-1- and LPS-dependent but not TNF-α-dependent activation of the IL-8 promoter." provenance.