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- _7 wasQuotedFrom 15578112 provenance.
- _7 value "Furthermore, constitutive activation of NF-kB by adenoviral expression of activated IkB kinase was sufficient to induce resistin in primary human macrophages (Figure 4E). The magnitude of this activation was less than that caused by LPS, which is known to also activate MAP-kinase (MAPK). Indeed, inhibition of either p42 MAPK by PD98059, or p38 MAPK (using SB20358) partially blocked the induction of resistin by LPS (Figure 4F). Together these results show that NF-kB activation is necessary and sufficient for resistin induction by LPS, with MAPK activation increasing the magnitude of the response. " provenance.