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- _4 wasQuotedFrom 11849969 provenance.
- _4 value "Mice lacking the IRS-1 protein are insulin resistant but do not develop overt diabetes. By contrast, animals lacking IRS-2 exhibit both impaired glucose tolerance and diabetes, which appears to result from a defect in insulin secretion as well as insulin resistance, presumably owing to decreased b-cell proliferation in the pancreas in the face of increased demand for insulin." provenance.