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- _5 wasQuotedFrom 15138278 provenance.
- _5 value "the ablation of FAS activity causes a dramatic down-regulation of Skp2, a component of the E3 ubiquitin ligase that controls the turnover of Kip1 protein. These effects ultimately tie into the retinoblastoma protein pathway and lead to a cell-cycle arrest at the G1/S boundary." provenance.