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- _3 wasQuotedFrom 12952954 provenance.
- _3 value "We initially analyzed mRNA levels of several mt translation factors by Northern hybridization. This revealed that differentiation of HL-60RG cells by TPA promotes coordinate reduction of the mRNA level for all mt translation factors investigated (Fig. 1A). Nuclear-coded genes, i.e. initiation factor 2 (IF-2mt), elongation factor Tu (EF-Tumt), elongation factor Ts (EFTsmt), methionyl-tRNA transformylase (MTFmt), methionyltRNA synthetase (MetRSmt), and ribosomal proteins S12mt and L7_L12mt were reduced by 10_20_fold, whereas mtDNAcoded 16 S rRNA was down-regulated to a lesser extent (5- fold) (Fig. 1A, 16 S rRNA). Similar results were confirmed with the HL-60 cell line (data not shown)." provenance.