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- _6 wasQuotedFrom 12468452 provenance.
- _6 value "Further evidence that PGC-1 promotes mitochondrial biogenesis was provided by the finding that cardiac-specific overexpression of PGC-1 in transgenic mice resulted in massive proliferation of mitochondria (27). The effect of PGC-1 on mitochondrial biogenesis is probably explained at least in part by the finding that in addition to being a coactivator of PPAR-gamma , PGC-1 coactivates NRF-1 (26) and PPAR-alpha (28)." provenance.