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- _4 wasQuotedFrom 17404574 provenance.
- _4 value "Whereas relatively few microRNA targets have been experimentally described, significantly, the prototypical anti-apoptotic protein Bcl-2 is a target of microRNA regulation. mir-15 and mir-16 have base complementarity (including the seed region) to the Bcl-2 mRNA, and overexpression of mir-15/16 leads to decreased Bcl-2 protein and increased cell death (Cimmino et al., 2005)." provenance.