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- _6 value "RCC cells lacking functional pVHL overexpress various growth factors, including platelet-derived growth factor b (PDGFb), VEGF and transforming growth factor (TGF)-a [25]. The latter is a bona fide renal-cell mitogen that activates the Ras–Raf–MAP kinase signalling cascade through its cognate epidermal growth factor (EGF) cell-surface receptor [26]." provenance.