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- _5 wasQuotedFrom 13130303 provenance.
- _5 value "In addition to effects on HIF-1a synthesis, activation of the RAF MEK ERK signalling pathway has also been shown to stimulate HIF-1a transactivation-domain function. This effect is due at least in part to phosphorylation by ERK of the co-activator p300, with which the transactivation domains interact." provenance.