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- _6 value "(Gerber et al., 1998). VEGF and aVb3 have been impli- cated in bone formation and metabolism (Gerber et al., 1999; McHugh et al., 2000), and the effects of VEGF165 stimulation on HUVEC adhesion to the bone matrix pro- tein, bone sialoprotein (BSP) VEGF165, even with incubation times up to 6 hr. The marked influence of VEGF165 on cell migration was demonstrable with a second aVb3 ligand. When HUVECs were provided with a BSP substrate, a substantial in- crease in HUVEC migration was observed when the cells were stimulated with VEGF165(Figure 2C)." provenance.