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- _4 wasQuotedFrom 12777400 provenance.
- _4 value "The results demonstrate that catalase, a major effector of the cellular defence against hydrogen peroxide, interacts with c-Abl and Arg. The results show that hydrogen peroxide induced binding of c-Abl and Arg to catalase. The SH3 domains of c-Abl and Arg bound directly to catalase at a 293 PFNP296 site. c-Abl and Arg phosphorylated catalase at Tyr-231 and Tyr-386 in vitro and in the response of cells to Hydrogen peroxide. The functional significance of the interaction is supported by the demonstration that cells deficient in both c-Abl and Arg exhibit substantial increases in hydrogen peroxide levels. Cells expressing Myc-catalase and c-Abl also showed phosphorylation of catalase at tyrosine. By contrast, tyrosine phosphorylation of catalase was inhibited in cells expressing c-Abl (K-R-inactive mutant). Catalase was also subject to tyrosine phosphorylation in cells expressing kinase-active Arg, but not kinase-inactive Arg (K-R- inactive mutant). The deletion of catalase 293 PFNP296 site abrogates the interaction between ABL1 and catalase." provenance.