Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAricfB624RZPnkdkyV1I2KHREC6UsbdeFls-RJVx4wIw#_6> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _6 wasQuotedFrom 17392790 provenance.
- _6 value "Here we report that the amino-terminal caspase recruitment domains (CARDs) of RIG-I undergo robust ubiquitination induced by TRIM25 in mammalian cells. The carboxy-terminal SPRY domain of TRIM25 interacts with the N-terminal CARDs of RIG-I; this interaction effectively delivers the Lys 63-linked ubiquitin moiety to the N-terminal CARDs of RIG-I, resulting in a marked increase in RIG-I downstream signalling activity. The Lys 172 residue of RIG-I is critical for efficient TRIM25-mediated ubiquitination and for MAVS binding, as well as the ability of RIG-I to induce antiviral signal transduction. " provenance.