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- _4 value "The inflammatory processes in CS-exposed lungs may be fueled through the potential cell survival activities provided by galectin-3 (lgals3) and osteopontin (opn/spp1) (Figs. 1 and 3, Table S8), which both function through activation of the antiapoptotic phosphatidyl inositol 3-kinase/protein kinase B (Akt) pathway (Lin and Yang-Yen, 2001Go; Oka et al., 2005Go; Zhu et al., 2005Go). " provenance.