Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAruK2Dpj20w0kAkYg8YWRMnRyhWX59dZE-7sK20u2vqQ#_5> ?p ?o ?g. }
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- _5 wasQuotedFrom 12893815 provenance.
- _5 value "Although the kinase activity of IRAK-1 increases strongly following IL-1 stimulation, IRAK-1 kinase activity is not required for its signaling function, because overexpression of a kinase-defective mutant of IRAK-1 is observed to strongly induce NF-κB activation in cells otherwise deficient for IRAK-1. Upon stimulation, IRAK-1 is recruited to the receptor through a homophilic interaction with the DD of MyD88." provenance.