Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAsI19SEiw4xXACh-Yv_w3pDORcqxkzY18rnwaatKI34I#_3> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _3 wasQuotedFrom 16449647 provenance.
- _3 value "Electrophoretic mobility shift assays and chromatin immunoprecipitation analysis showed the binding of CREB to the PEN-2 promoter region both in vitro and in vivo. Activation of the CREB transcriptional factor by forskolin dramatically promoted the expression of PEN-2 mRNA and protein, whereas the other components of the gamma-secretase complex remained unaffected. Forskolin treatment slightly increases the secretion of soluble APPalpha and Abeta without affecting Notch cleavage. These results demonstrate that expression of PEN-2 is regulated by CREB and suggest that the specific control of PEN-2 expression may imply additional physiological functions uniquely assigned to PEN-2" provenance.