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- _4 wasQuotedFrom 16530485 provenance.
- _4 value "During the course of cell-cycle progression through the restriction point, RB becomes hyperphosphorylated, thereby releasing E2F and causing its activation. Among the different E2F proteins, E2F1 is the best-understood factor owing to its dual function: it triggers both proliferation and apoptosis via activation of downstream target genes" provenance.