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- _6 value "Chapter 14: Only the membranes from activated Th cells induce B-cell proliferation, suggesting that one or more molecules expresed on the membrane of an activated Th cell engage the receptors on the B-cell to provide contact dependent help. Likely mediators of such contact-dependent help are CD40, which is expressed on the membrane of all B-cells, and its newly discovered ligand, CD40L, which is expressed on the membrane of activated Th cells." provenance.