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- _7 wasQuotedFrom 16169070 provenance.
- _7 value "background: (from text) Axin-1 is a negative regulator of the Wnt pathway that controls the levels of the transcriptional activator ?-catenin (Behrens et al., 1996). In the absence of Wnt signals, ?-catenin is degraded by an Axin-1-containing multiprotein complex , while activation of the pathway with, e.g., dishevelled (Dvl) inhibits ?-catenin degradation and induces Lef/Tcf-dependent transcription (Huelsken and Birchmeier, 2001). evidence: (from text) In the assay, moderate overexpression of Dvl in HEK293 cells caused a 4-fold increase in reporter gene activity. However, this increase was reduced to 1.5-fold in a dose-dependent manner, when full-length ANP32A or CRMP1 were coexpressed (Figure 6C). The activity of protein fragments in the Wnt signaling assay correlated with their ability to bind Axin-1. " provenance.