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- _6 value "In cells transfected with negative mutants of IKKα, IKKβ, and NIK, IL-1β-induced κB luciferase activity were inhibited by 32 ± 7%, 70 ± 11%, and 33 ± 8%, respectively (Fig. 1D). Compared with the distinct selectivity for IL-1β action, IKKα and IKKβ mutants reduced the NIK-induced κB response to a similar extent (Fig. 1D)." provenance.