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- _4 wasQuotedFrom 12225989 provenance.
- _4 value "Mobility shift assays revealed that HSP60 induced NF-kappaB and CRE binding activity, while CCAAT/enhancer binding protein (C/EBP), which binds to NF-IL-6, was constitutively active in the cells. CREB and c-Jun bind CRE regulatory regions in responsive gene promoters. HSP60, like LPS, readily activated CRE in macrophages. Both c-Jun and CRE binding protein (CREB) bound to the CRE, while C/EBP-beta bound to NF-IL-6. These data indicate that NF-kappaB, C/EBP-beta, c-Jun, and CREB are important in HSP60-induced expression of COX-2." provenance.