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- _6 value "Hyperoxia was associated with a significant increase in pJNKs and pERKs in WT mice as seen by Western blot. NOX1, but not NOX2, deficiency decreased ERK and JNK phosphorylation without modification of JNK and ERK protein levels (Figures 7A?7F).NOX1, but not NOX2, deficiency decreased ERK and JNK phosphorylation without modification of JNK and ERK protein levels (Figures 7A?7F). pERK staining was associated with type II pneumocytes and endothelial cell markers during hyperoxia (Figure 8A), whereas pJNK staining was detected mainly in endothelial cells (Figure 8B). " provenance.