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- _3 wasQuotedFrom 16863918 provenance.
- _3 value "In general, proinflammatory cytokines and TLR ligands suppressed mCMKLR1 expression (Fig. 5, upper panel). We observed the following hierarchy in mCMKLR1 suppression by TLR ligands: LPS O polyI:C O CpG. The proinflammatory cytokines IFN-g and TNF-a caused modest mCMKLR1 suppression as well, which was enhanced by coincubation with LPS. Interestingly, the immune-suppressive cytokine TGF-b had the opposite effect on receptor expression: overnight treatment with either TGF-b1 or TGF-b2 resulted in mCMKLR1 upregulation" provenance.