Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ#_4> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _4 wasQuotedFrom 15642134 provenance.
- _4 value "Incubation of PBMCs with 10 microgram/ml anti-CD3 significantly upregulated IL-17 production upto 3.7 fold, and combination of anti-CD3 and anti-CD28 produced more IL-17 (approximately 1.3-1.5 fold) than anti-CD3 alone. Furthermore, treatment with LY294002 and wortmannin, inhibitors of PI3K, and PDTC, NFkB inhibitor markedly blocked the anti-CD3 and anti-CD28 induced IL17 protein and mRNA production in a dose dependent manner. This indicates that CD3 and CD28 induced IL-17 production was mediated by PI3K pathway." provenance.