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- _3 wasQuotedFrom 11246888 provenance.
- _3 value "Incubation...with LA, PA, and SA significantly increased Mo LPL mRNA expression. expose of macrophages to AA and EPA dramatically decreased LPL mRNA levels... These results suggest that FAs, including PA, SA, and AA, might exert their regulatory effect on Mo LPL gene expression, at least partly, through a PPAR-dependent mechanism. Indeed, we found that these well-characterized ligands and activators of PPARs (49) directly regulate Mo LPL gene expression and enhance the binding activity of nuclear proteins to the PPRE element present in the LPL gene in a PPAR-specific manner." provenance.