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- _6 wasQuotedFrom 11711431 provenance.
- _6 value "Transforming growth factor-beta (TGF-beta) is a potent inhibitor of skeletal muscle differentiation, but the molecular mechanism and signaling events that lead to this inhibition are poorly characterized. Here we show that the TGF-beta intracellular effector Smad3, but not Smad2, mediates the inhibition of myogenic differentiation in MyoD-expressing C3H10T1/2 cells and C2C12 myoblasts by repressing the activity of the MyoD family of transcriptional factors. Central to the induction of myogenic differentiation is the function of the MyoD family of basic helix-loop-helix (bHLH) transcription factors, which include MyoD, myogenin, Myf5, and MRF4 and are collectively referred to as myogenic regulatory factors or MRFs" provenance.