Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAwsIeKFLQCFbbBan-Nbu0dzEybwyB7wkKYzJm30OCoiQ#_6> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _6 wasQuotedFrom 21321929 provenance.
- _6 value "c-Abl is an upstream regulator of the profibrotic PKCdelta/phospho-Fli-1 pathway, via induction of PKCdelta nuclear localization. Additionally, the finding that Fli-1 is phosphorylated (Thr312 phosphorylation) at higher levels in SSc fibroblasts supports the notion that the c-Abl/PKCdelta/phospho-Fli-1 pathway is constitutively activated in these cells. Thus, blocking the TGFbeta/c-Abl/PKCdelta/phospho-Fli-1 pathway could be an attractive alternative approach to therapy for scleroderma." provenance.