Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAxnn3iQjvwkdBkkZnrI-s51QOH2ABPF9TqL1VwOpwX6Q#_5> ?p ?o ?g. }
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- _5 wasQuotedFrom 14988727 provenance.
- _5 value "cells. Transfected SPAK synergized with constitutively active PKCtheta to activate AP-1, but not NF-kappaB. This synergistic activity, as well as the receptor-induced SPAK activation, required the PKCtheta-interacting region of SPAK, and Ser-311 mutation greatly reduced these activities of SPAK. Conversely, a SPAK-specific RNAi or a dominant-negative SPAK mutant inhibited PKCtheta- and TCR/CD28-induced AP-1, but not NF-kappaB, activation." provenance.