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- _4 wasQuotedFrom 19351856 provenance.
- _4 value "Interestingly, Dkk-1, encoding a Wnt signaling antagonist frequently silenced by DNA methylation in cancer cells (20, 26), was down-regulated in a dose-dependent manner in both cell lines. Quantitative RT-PCR experiments (Fig. 1C) confirmed that TSC mediated dose-dependent decreases in Dkk-1 mRNA copy numbers in A549 and Calu-6cells, which exhibited relatively high Dkk-1 expression." provenance.