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- _5 wasQuotedFrom 16170185 provenance.
- _5 value "C-Raf exists in the cytoplasm as a 300- to 500-kd protein complex. The complex consists of C-Raf, heat shock protein 90 (Hsp90), and the dimeric protein cofactor 14-3-3. 14-3-3 binds to two specific phosphoserine residues of C-Raf, which masks its kinase domain and inactivates the protein. The binding of Ras to C-Raf displaces the 14-3-3 dimer, rendering C-Raf accessible to dephosphorylation by protein phosphatase 2A.126" provenance.