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- _3 wasQuotedFrom 17638880 provenance.
- _3 value "VEGF-A mRNA had a higher basal expression level in wild-type cells than in mutant cells (Supplementary Fig. S5B). In addition, both hypoxia and glucose deprivation led to a significant up-regulation of VEGF transcripts in wild-type MEFs but not in IRE1a ( -/- ) MEFs, thus confirming the essential role of IRE1 signaling in the regulation of VEGF-A expression under hypoxia or in the absence of glucose." provenance.