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- _5 wasQuotedFrom 12559172 provenance.
- _5 value "The extrinsic pathway is activated in vivo by TNF family ligands that engage DD-containing receptors, resulting in activation of DED-containing caspases. The 'death ligands' are expressed on CTLs, NK cells, and other types of immune-relevant cells (activated monocytes/macrophages and dendritic cells) and are used as weapons for eradication of transformed cells (Locksley et al., 2001). tumor suppression by cellular immune mechanisms. For example, Fas-Ligand (FasL) is important for CTL-mediated killing of some tumor targets, and TRAIL (Apo2- Ligand) is critical for NK-mediated tumor suppression." provenance.